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Acknowledgements The authors thank all investigators and staff involved in the conduct of this clinical trial

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Cancer cell senescence is primarily caused by oncogene-induced senescence (OIS) or therapy-induced senescence (TIS)

The D 2 O 2 -soaked and reduced Trp161Phe MnSOD neutron datasets were collected from crystals grown in microgravity, while all other data sets were from crystals grown on Earth

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