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In general, yes especially since excess B12 is typically excreted

For example, in several warning letters the agency articulates that: Drugs must be manufactured in conformance with cGMP

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For example, area 25 activity could be correlated with cortisol output if it were providing a direct stimulatory input to the HPA axis, or if it were activated by increasing concentrations of circulating cortisol to exert negative feedback

doi: 10.1042/bj3110911