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Furthermore, HK-2 did not show any adverse effects in rats [154,155,156], suggesting that HK-2 is a new therapeutic option for NIHL

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Because the activity of the QDPR gene encoded enzyme is also involved in the functions of the tyrosine hydroxylase and tryptophan hydroxylase enzymes, mutations in the QDPR gene present as atypical hyperphenylalaninemias but are also associated with the potential for microcephaly, hypotonia, intellectual impairment, and convulsions due to neurotransmitter synthesis deficits

These effects are often visible within days of treatment, with cumulative improvements over time