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Interestingly rats given p53 inhibitors and amifostine did not have improved survival compared to controls, suggesting amifostine acts (at least in part) via a p53 dependent mechanism [55]

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Serum IGF-I levels alone are usually insufficient for diagnosing AGHD, so provocative tests such as the insulin tolerance test, glucagon stimulation test, or the combined GHRH-arginine test (where available) are needed (28)