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Role of melatonin in the prevention of morphine-induced hyperalgesia and spinal glial activation in rats: protein kinase C pathway involved

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We list it as our high-potency pick for two specific scenarios: anyone with documented deficiency working to replete liver stores, and anyone whose absorption is significantly compromised (long-term metformin + PPI combination, post-bariatric surgery, atrophic gastritis on biopsy)

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