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Human topoisomerase I was acquired from Sigma
Eurasian J Med (2018) 50(3):193201
There is a psychological component too
Growth factors such as fibroblast growth factor bind heparan sulfate proteoglycan (HSPG) and are enzymatically cleaved and released as soluble ligands 98
2024 doi: 10.2174/0115748928315442240624120104
This, coupled with a lack of sensitive and specific diagnostic markers, and quantitative biomarkers of progression, has hampered clinical trials for disease modification in PD 3
