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RNA-seq experiment and data analysis Total RNA was extracted from the cotyledons of Mock and pER8-LEC2 at 72, 84, and 96 HAI and then sent to Shanghai OE Biotech Company (China) for library preparation and deep sequencing

PPA exposure produced pronounced oxidative stress and disruptions in lipid metabolism, whereas post-treatment with omega-3 or vitamin B12, administered individually or together, partially normalized antioxidant defenses, modulated inflammatory enzyme activity, and altered microbial profiles

The ability of gut to sequester harmful microbes declines with age

PD patients frequently exhibit dysbiosis, characterized by: Reduced short-chain fatty acidproducing bacteria (e.g., Faecalibacterium )

Some patients prioritize a high quality of life even if it means acknowledging the potential shortening of their lifespan