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Ultimately, elucidating the mechanisms that govern transitions between protective and pathological states will be critical to refine classification systems and to guide therapeutic strategies targeting astrocyte reactivity

There is also growing evidence that neurodegenerative diseases such as Alzheimer's and Parkinson's may be caused by detrimental environmental and dietary factors that alter gene expression by means of DNA methylation and histone modification [3]

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Central diabetes insipidus relates to pathologies that affect the hypothalamus or the pituitary resulting in defects in vasopressin (antidiuretic hormone, ADH) synthesis or release

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These infants required ventilatory support and high concentrations of supplemental oxygen therapies that induced lung damage with regions of atelectasis and regions of hyperinflation, epithelial injury, hyperplasia of airway smooth muscle, fibrosis, and pulmonary vascular hypertension