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In the current era of single-cell analysis, a computational model for studying metabolic phenotypes in the tumor microenvironment at a single cell level has also been developed (100), along with methods for imaging single-cell behavior in various microenvironments (101)

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Acknowledgements This Research was supported by the Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health Intramural Research Program project number ZIA BC 010441 and federal funds from the National Cancer Institute, National Institutes of Health, under contract HHSN261201500003I

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Barnes-Velez, J