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TCA-CYCLE INTERMEDIATES GENERATE CYTOSOLIC AND MITOCHONDRIAL NADPH Isocitrate and malate are two TCA-cycle metabolites that generate NADPH through mitochondrial and cytosolic forms of isocitrate dehydrogenases (IDH1 and IDH2) and malic enzymes (ME1 and ME3), respectively

(Lausanne) 13 , 869414 (2022)

Chen Y, Pan G, Wu F, Zhang Y, Li Y, Luo D

( In fact, others have also found that targeting antioxidant capacity using different interventions such as methylcobalamin, folinic acid ( Significant improvements in the glutathione levels of children with ASD were also confirmed in this study using a nutritional approach known to increase glutathione biosynthesis

Yousefi-Manesh H, Shirooie S, Noori T, Sheibani M, Tavangar SM, Hemmati S, Sadeghi MA, Akbarniakhaky H, Mohammadi Z, Foroutani L, Dehpour AR (2023) Spermidine reduced neuropathic pain in chronic constriction injury-induced peripheral neuropathy in rats

The pharmacokinetics of 2-O-methyl phosphorothioate antisense oligonucleotides: experiences from developing exon skipping therapies for duchenne muscular dystrophy