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Water-soluble Mn(II) salts, such as MnCl and MnSO, are readily absorbed following inhalation or oral exposure, resulting in greater systemic bioavailability than poorly soluble Mn(III) and Mn(IV) oxides (e.g., MnO and MnO), which show limited gastrointestinal absorption 33

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Among these are ABCA7, PICALM, CLU, TREM2, APOE, SORL1, GSK3B, and PRNP (see Figure 3), which are not associated with hereditary forms of the disease but play a crucial role in the accumulation of -amyloid proteins, synaptic dysfunction, and neuroinflammation (35, 51)