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Although studies merely on animal models and genome-wide analyses have strongly supported the scientific progression in our knowledge of this disorder, further studies are advocated to improve our understanding of MVP predisposition, to possibly identify some specific biomarkers and pathogenetic pharmacological targets, therefore providing a complementary aid to interventional treatment that yet remains the only curative option for these patients

Acknowledgments We acknowledge the support and help from Damian J

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Redox control of protein degradation