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Cancer research 74: 31993204, 2014

The increased oxidative stress in tumor cells necessitates a reliance on elevated MTH1 expression for maintaining cellular functionality

Similar content being viewed by others Introduction Cancer remains one of the world's most devastating diseases with more than 10 million new cases each year and radiotherapy is a leading cancer treatment approach that addresses the needs of more than 50% cancer patients 1

However, these associations should not be interpreted as evidence that within-cycle changes in biomarker concentrations necessarily reflect altered dietary requirements, as plasma volume shifts, inflammatory tone, and insulin sensitivity also vary across the cycle and may influence circulating concentrations independently of intake