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TLDR: we will be watching this space and reporting as we go

However, the efficacy of vitamin B 12 supplementation in treating CVDs remains a subject of ongoing debate [97,98,99]

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doi: 10.1016/s0140-6736(20)30183-5 141 RadhouaniMFarhatAHakobyanAZahalkaSPimenovLFokinaAet al

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Thus, although autophagy is modulated by ROS, autophagy also has a feedback loop to regulate ROS levels through transcription factor (NRF2, p53) activation or the degradation of damaged components, such as mitochondria, peroxisomes and unfolded proteins, as discussed below (Fig