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The activity of several protein kinases, and particularly of protein kinase C (PKC) sub-family members can be modulated in human neuronal cells supplemented with tocopherols and tocotrienols (Galli et al., 2017)

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The long-term open label extension of the Japanese Early-Stage Trial of High Dose Methylcobalamin for Amyotrophic Lateral Sclerosis (JETALS) completed enrollment in March 2025 (NCT03548311), with the medication showing good tolerability at an interim analysis performed in early 2024 [161]

Caputi and OConnor generated plant-derived MIA derivatives by incubating various halogen- and methoxy-decorated tryptamine analogs and secologanin with strictosidine synthase (STR) from Catharanthus roseus

The discrepancies between the results of the straight knockout studies and those of shRNA knockdown studies likely resulted from the distinct experimental approaches used for inhibiting/blocking TB4 [79,90,91,92]