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Meanwhile, the upregulation of MDM2 suggests that the p53 signaling pathway may be inhibited, which to a certain extent reduces the ability of cells to repair DNA damage and may prompt cells to evade apoptotic mechanisms, further accelerating tumor progression

[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Foyer C.H., Theodoulou F.L., Delrot S

The combination of reduced insulin levels and increased fat oxidation creates conditions favorable for hepatic ketogenesis