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Apricoxib, mentioned above is an anticancer NSAID, having 1,2-diphenyl moiety attached to a central 5-membered pyrrole ring together with a para -SO 2 NH 2 PGHS-2-specific pharmacophore [224]

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Trx1 overexpression downregulates ATG4B, LC3-II, histone D and LAMP2a, and counteracts ACR-induced autophagy, while Trx1 suppression triggers autophagy (132)

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