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PMC 2064426
This knockdown also induces lactylation at the K73 site in ADP-ribosylation factor 1 (ARF1), which affects vesicle assembly and induces mitochondrial loading abnormalities, thereby blocking the release of mitochondria from astrocytes, ultimately exacerbating the extent of brain infarction in mice
Karuppagounder SS, Alin L, Chen Y, Brand D, Bourassa MW, Dietrich K, et al
Clin Lung Cancer 23(5):e335-e338, 2022
189 Further, ME1 treated with the inhibitor (piperazine-1-pyrrolidine-2,5-dione) has little effect on normal rat intestinal epithelial cells but strongly suppresses human CRC cell growth by targeting ME1 NADP + -binding site and reducing the NADPH level
About this article Cite this article Liu, Y., Wang, X., Feng, H
