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The limitations of this work are that we included RCTs, non-RCTs, and observational studies, which may lower the overall quality of evidence of the included studies

Aged muscle stem cells treated with NNMT inhibitors regain proliferative capacity and regenerative function, reversing cellular senescence that normally accumulates with age

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A study found even healthy people with higher levels of a blood marker linked to these deficiencies were more likely to feel exhausted or unmotivated

However, such drugs are not causes of B12 deficiency