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Key Takeaways Tirzepatide is an FDA-approved medication for type 2 diabetes and weight loss, acting as a dual agonist of GLP-1 and GIP receptors, which helps regulate blood sugar, suppress appetite, and slow gastric emptying

Sarriera JE, Albitar M, Estrov Z, Gidel C, Aboul-Nasr R, Manshouri T, Kornblau S, Chang KS, Kantarjian H, Estey E

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a targeting moiety binds to EphA2 or EphA4 on cancer cells (e.g., EphA2 or EphA4 not bound to a ligand) rather than EphA2 or EphA4 on non-cancer cells (e.g., EphA2 or EphA4 bound to a ligand)

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