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GCAgNPs bind to the peptidoglycan membrane destroyed the lipopolysaccharide barrier, and penetrated the membrane protoplasm, also increasing ROS production due to contact with intracellular components and scavengers' depletion (Guzmn et al., 2019)

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The T allele of this polymorphism has been linked to increased CAT transcriptional activity (Wu et al., 2023)

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Subsequent sections will provide a detailed analysis of how MPs/NPs exacerbate PD progression through specific pathways: promoting aberrant -synuclein aggregation, inducing neuroinflammation, disrupting gut-brain axis homeostasis, interfering with mitochondrial energy metabolism, inhibiting the excitatory amino acid transporter 2(EAAT2), and triggering ferroptosis
