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The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon

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It is also important in the formation of myelin sheath around the nerves and also in the transmission of nerve impulses

Radiation induces M2 polarization of glioma-associated macrophages via upregulation of glutamine synthetases

This involves a decrease in the expression levels of E-cadherin and an increase in the expression levels of mesenchymal genes such as vimentin (Oh et al., 2018)

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