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This innovation offers a therapeutic strategy to eliminate lactate from the TME and improving radiotherapy efficacy for uveal melanoma (UM)

How Zepbound Works Compared to Other Weight Loss Medications Head-to-Head Comparison: SURMOUNT-5 Trial The first head-to-head trial, Tirzepatide as Compared with Semaglutide for the Treatment of Obesity (Aronne et al., New England Journal of Medicine , 2025), randomized 751 adults with obesity but without diabetes to tirzepatide or semaglutide for 72 weeks

Fasting shifts substrate utilization toward fatty acids and ketone bodies, with -hydroxybutyrate serving not only as an efficient energy source but also as a signaling molecule

Chao X, Wang S, Ding W-X

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M., Liu, C