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Thyroid enlargement, or goiter, is one of the earliest and most visible signs of iodine deficiency

the ratio between GSH and GSSG is held in dynamic balance depending on many factors including the tissue of interest, intracellular demand for conjugation reactions, intracellular demand for reducing power, extracellular demand for reducing potential, and the complex interplay between several regulatory enzymes including glutathione peroxidase (GPx), glutathione- S -transferase (GST) and -glutamyltransferase (GGT)

Furthermore, the results reported that most of the hydrophobic face of the PNC-27 peptide, is composed of residues 6-15 in the HDM-2-binding domain