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Atherosclerosis: TMAO Activates ERS The ER, formed in continuity with the outer membrane of the nuclear envelope, plays a key role as a central eukaryotic membranous organelle and is responsible for the synthesis, folding, and maturation of membrane and secreted proteins, lipid biosynthesis, and calcium storage (67)

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Next, we used publicly available RNA-Seq data from HeLa cells obtained from control and ELAVL1 knockdown cells 27 to assess differential exon expression and predict genes regulated by HuR

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This enhanced oxidative stress leads to cell damage resulting in various complications such as sepsis, myocardial injury and increased mortality

Smith JF, Shindel AW, Huang YC, Clavijo RI, Flechner L, Breyer BN, et al