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Plant-derived secondary metabolites offer improved regulation over Nrf2/Keap1/ARE pathway with lower risk of acute and chronic complications

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If the ratio falls too low, the highly oxidized environment triggers cell cycle arrest or programmed cell death (apoptosis), leading to widespread tissue damage and profound fatigue

Environ Res 103:238246 Gagn F, Andr C, Blaise C, Pellerin J, Sherry J, Talbot A (2009) An investigation of the disruptive effect of pollution in cold- and warm-adapted clam populations

Usually transient and dose-dependent

doi: 10.1186/s12974-016-0752-y