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Some protocols call for an initial loading phase (e.g

Its likely that a combination of factors is at play. MS-specific studies, including one published in February 2026 on PubMed Central , say that low sun exposure, Vitamin D deficiency, using tobacco, lack of exercise, and obesity are some of the leading causes of MS onset

Systemic effects from topical application are rare but not impossible with very high concentrations or compromised skin barriers

People who have gastrointestinal disorders like celiac disease or Crohn's disease or who have undergone weight-loss surgery may secrete too little hydrochloric acid or intrinsic factor

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