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Consequently, SOD2 activity is approximately 40% higher following the mitochondrial import in the SOD2 Ala precursor compared to its Val counterpart ( SOD2 rs4880 polymorphism is believed to be associated with the susceptibility to various diseases, including cancer, neurodegenerative disorders, chronic kidney disease (CKD), and cardiovascular diseases ( The SOD3 gene encodes for superoxide dismutase three playing a pivotal role as an extracellular antioxidant enzyme

According to Sanzani et al

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doi: 10.1007/s00424-022-02671-1

and ferroportin (FPN), whose expression is suppressed to reduce iron export ( Ferritinophagy, a selective autophagic process mediated by the cargo receptor NCOA4, plays a pivotal role in iron release by targeting ferritin for lysosomal degradation ( Additional systemic and local factors further modulate iron homeostasis