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PMID 28624304

We detected the levels of IL-1 and TNF-, which indicate the inflammatory response of chondrocytes induced by MIA (Fig

Twenty-one days after the primary immunization, the mice were boosted with a secondary immunization with same amount of CII emulsified in incomplete Freunds adjuvant (Sigma) intradermally in the tail proximal to the primary injection site

The accepted daily supplement recommendation is 6001,800 mg of NAC (29)

Funding This research was funded by National Key Research and Development Program of China, grant number 2018YFD1000103 and 2020YFD1000102, and National Natural Science Foundation of China, grant number 31772250

Compared to CBCs (cluster2 and cluster3), revSCs (cluster1) exhibited significant upregulation of genes associated with cellular stress protection, including glutathione S-transferase family members 49 , Bcl2 family genes 50 , and heat shock protein family genes 51 (Fig