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Description
Limitations and Research Status While preclinical data is extensive, large-scale human clinical trials are limited
However, this metabolic addiction can be lost in the tumour microenvironment, rendering GLS inhibitors ineffective in the clinic
This causes a self-perpetuating cycle of damage.* The cell maintains efficiency through a natural response called mitophagy
Indeed, when cultured in absence of serine/glycine, control cells exhibited impaired proliferation, while NKX2-1 overexpressing cells continued to proliferate, showing that increased serine/glycine synthesis enables cancer cells to become independent of exogenous serine for proliferation
It may be relevant to research into: Connective tissue signalling and recovery models Regeneration and cell migration pathways Mechanisms associated with physical stress and tissue integrity Capsule format supports consistent, accurate handling Designed for structured protocols Always follow the product label directions This Density Labs product is strictly intended for in vitro laboratory research by qualified professionals
doi: 10.1016/j.intimp.2023.111433 116 JiangXLuZZhangQYuJHanDLiuJet al
