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(2007) Function of the Caenorhabditis elegans ABC Transporter PGP-2 in the Biogenesis of a Lysosome-related Fat Storage Organelle

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Receptors are known to exhibit broad activity, which researchers have used to probe how these systems function in the body under laboratory conditions

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Simplistically, when cholesterol in the plasma membrane is in excess for any reason, e.g., after LDL uptake by receptor-mediated endocytosis, there is a rise in accessible (or 'active') cholesterol, some of which is transferred to the nascent HDL, but much is returned to the endoplasmic reticulum to switch off cholesterol biosynthesis and expression of the LDL receptor