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In gastrointestinal injury models where vehicle-treated animals may show reduced food intake and body mass due to the effects of the experimentally induced lesion, BPC-157-treated groups have been reported to show better preservation of body mass, which is more consistent with gastrointestinal cytoprotection than direct body mass regulation

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Rev Soc Bras Med Trop

This leads to the development of hypoxia (decreased oxygen levels) in intestinal epithelial cells and activation of hypoxia-inducible factor alpha (HIF-1) (Wu et al., 2020)
