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The tripeptide maintains cellular redox homeostasis through the glutathione redox cycle, where NADPH-dependent glutathione reductase continuously regenerates GSH from GSSG

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Discontinue use if irritation occurs and rinse with water

[DOI] [PubMed] [Google Scholar] 131.Stojanovska L, Honisett SY, Komesaroff PA

Skin in these areas is often thinner and more sensitive than the face, so beginning with every-other-night application and monitoring for irritation is especially important

Scientific References (External Links) Nature Chemical Biology: Small molecule inhibitors of nicotinamide N-methyltransferase View Study Biochemical Pharmacology: Nicotinamide N-methyltransferase: A promising target for treating metabolic disorders View Study FASEB Journal: Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity in mice View Study Journal of Biological Chemistry: Inhibition of nicotinamide N-methyltransferase in vivo regulates cellular energy metabolism View Study