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CNS target engagement will be assessed by measuring levels of key senescence markers in CSF at baseline and after three months treatment with senolytics

Intramuscular injection (accidental) Not an approved route

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Apoptotic signaling, oxidative stress, and mtDNA damage collectively exacerbate neuroinflammation and neurodegeneration (McGovern and Barreto, 2021) propagation in the long term (De Gaetano et al., 2021