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Clinical trials show that patients on GLP-1 therapy lose an average of 12 pounds per week during active titration, with cumulative losses ranging from 1020% of body weight over 6 months when combined with healthy eating and physical activity

According to Jennifer Norris, PA-C, a medical weight management specialist at Duke Health, GLP-1s are often hyped as 'miracle drugs', but the reality is more nuanced

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Summary Phentermine combined with topiramate has been shown to promote significant weight loss and may help reduce the incidence of binge-eating episodes

They found that while the blood brain barrier kept liraglutide from dispersing throughout the brain, the drug was able to slip into the circumventricular organs