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The redox state significantly influences the gut microbiota's composition and activity, affecting microbial metabolism and their interactions with the host

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In vitro , myricetin treatment of SH-SY5Y neuroblastoma cells exposed to 1-methyl-4-phenylpyridine (MPP + ) significantly reduces Fe 2+ and ROS levels, activates the NRF2/GPX4 signaling pathway, suppresses neuronal ferroptosis, and mitigates cellular injury (Gu et al., 2024)

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76 p53 suppresses tumor through regulating its target gene, glutamine synthase 2 (GLS2), which exerts antioxidant defense function

Under physiological conditions, Nrf2 activation protects cells against oxidative insults by upregulating cytoprotective genes