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1 Vitamin B 12 has been demonstrated to be safe in doses up to 1,000 times the recommended dietary allowance and is safe in pregnancy
Overdiagnosis: B12 deficiency As part of our series on conditions that may be overdiagnosed, GP partner and trainer Dr David Coleman considers why and when we might be placing too much stock on vitamin B12 deficiency Background Vitamin B12 deficiency is a relatively common condition with a range of causes and innumerable symptoms
A randomised controlled trial randomising 149 women with clomiphene-resistant PCOS (133 analysed) at a single Karachi centre, published in the Journal of Reproduction & Infertility , found that adding CoQ10 to clomiphene citrate raised ovulation rates from 19% to 70%, with women receiving the combination roughly six times more likely to conceive than those on clomiphene alone (adjusted OR 6.34, 95% CI 1.4527.71)
In this paper, Dr
they conclude that the differences in metabolism are due to immature glucuronidation and that sulphation is the major route of excretion [49]
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