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Abbreviations COPD: Chronic obstructive pulmonary disease DDS: Drug delivery system ROS: Reactive oxygen species RNS: Reactive nitrogen species iNOS: Inducible nitric oxide synthase isoenzymes PM: Particulate matter SLPI: Secretory leukocyte protease inhibitor 1AT: Alpha-1-antitrypsin IL: Interleukin NF-B: Nuclear factor kappa B IL-8: Interleukin-8 GM-CSF: Granulocyte macrophage colony-stimulating factor SOD: Superoxide dismutase GPx: Glutathione peroxidase iNOS: Inducible nitric oxide synthase HDAC: Histone deacetylase EGFRs: Epithelial growth factor receptors BHR: Hyperresponsiveness P13K: Phosphoinositide 3-kinase TGF: Transforming growth factor MMP: Matrix metalloproteinase MUC5AC: Ne, neutrophil elastase TNF: Tumor necrosis factor CCL: CC-chemokine ligand CCR: CC-chemokine receptor CXCL: CXC-chemokine ligand CXCR: CXC-chemokine receptor T H 1: T helper1 cells T C 1: Type 1 cytotoxic NO: Nitric oxide ONOO : Peroxynitrite DPPC: L-a-dipalmitoylphosphatidyl-choline CAT: Catalase NAC: N-acetylcysteine TBARS: Thiobarbituric acid reactive species HBA: P-Hydroxybenzyl alcohol Trolox: Antioxidant and water-soluble analogue of Vitamin E Al 2 O 3 NPs: Aluminum oxide nanoparticles FP: Fluticasone propionate HPH: High-pressure homogenization PLGA: Poly(lactide-co-glycolide) PEG-DSPE: Polyethylene glycol and phosphatidylethanolamine PVP: Polyvinylpyrrolidone PVA: Polyvinyl alcohol PGA-co-PDL: Poly (glycerol adipate-co--pentadecalactone DOTAP: Dioleoyltrimethy- lammoniumpropane PLA: Poly(lactic acid) PEG: Polyethyleneglycol pHDAC2: HDAC2-encoding plasmid DNA MnPD: Mn-porphyrin dimer DESE: Double emulsion solvent evaporation method HPOX: HBA-incorporated copolyoxalate LPS: Lipopolysaccharide COX-2: Cyclooxygenase-2 U937: Human leukemic monocyte lymphoma cells CeNPs: Cationic cerium oxide nanoparticles CDs: Carbon dots SLNs: Soild lipid nanoparticles HPOX: Hydroxybenzyl alcohol-incorporated polyoxalate LPNs: Lipidpolymer hybrid nanoparticles SiO 2 NPs: Silica nanoparticles MABAs: Muscarinic antagonist and 2 agonist properties MMAD: Median mass aerodynamic diameter SFD: Supercritical fluid NCMPs: Nanocomposite microparticles MF: Mometasone furoate SX: Salmeterol xinafoate SBS: Salbutamol sulphate Nrf2: Dimethyl fumarate activator 2 BD: Budesonide RES: Resveratrol HA: Hyaluronic acid HSPB5: Alpha B-crystallin DEX: Dexamethasone PVAX: Polyvinyl alcohol-containing copolyoxalate HPH: High-pressure homogenization SX: Salmeterol Xinafoate FP: Fluticasone Propionate TPGS: D--tocopherol polyethylene glycol 1000 succinate BSA: Bovine serum albumin FPF: Fine particle fraction LPPs: Large porous microparticles SLMs: Solid lipid microparticles NCMPs: Nanocomposite microparticles PRINT: Particle Replication In Non-wetting Templates References Qaseem A, Wilt TJ, Weinberger SE, et al

2 This is due to lactational amenorrhea, the temporary period in which a postpartum woman is breastfeeding and not menstruating, thus reducing her iron loss

These cells are often on the "front lines," where oxidative stress is highest

The enrichment of MFeI and MFeI MNs in the brain was detected after applying either of the two administration strategies: intravenous MFeI and in situ MFeI MNs