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The most frequently reported side effects in the SURMOUNT clinical trials included gastrointestinal symptoms such as nausea (25-29%), diarrhea (21-23%), vomiting (8-9%), constipation (17-20%), and abdominal pain (8-9%)

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Pollak 2008) has linked elevated circulating IGF-1 to higher risk of certain cancers in human cohorts

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