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What are Macrophages

In the present review, we will focus mainly on the signaling cascade of TLR4 because it is believed to be the main sensor of bacterial LPS (Ignacio et al., 2016)

In the acute phase, symptoms include euphoria, anxiety, paranoia, and psychomotor agitation, which are primarily caused by the short-term overactivation of neurotransmitter systems ( 2.3.1 Cognitive impairment METH abuse significantly impairs cognitive function by targeting key brain regions ( 2.3.2 Psychiatric symptoms METH abuse disrupts the functionality of various brain regions, including the prefrontal cortex, nucleus accumbens, and thalamus, leading to significant psychiatric disturbances ( 2.3.3 Motor dysfunction Motor dysfunction caused by METH abuse is commonly characterized by parkinsonian-like symptoms, including tremors, bradykinesia, and rigidity ( 2.4 Auxiliary examinations Auxiliary examinations, particularly neuroimaging and neurochemical analyses, play a crucial role in identifying functional and structural changes in the nervous system caused by METH abuse

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