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Urology 133 , 7883 (2019)

However, it's important to note that comprehensive human clinical trials remain limited, and most safety and efficacy data comes from animal studies

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A patient suffering from severe, treatment-refractory hyperadrenergic POTSexperiencing debilitating tachycardia, tremors, and massive adrenaline surgeswas found to have a genetic polymorphism in their COMT pathway