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Overall, pFeSAN possesses a higher degree of graphitization and abundant nitrogen defect, indicating that the designed biomimetic synthetic strategy enables the effective modulation of the local electronic structure of Fe in pFeSAN and thereby affect their enzyme-like activity

The most important of these are polymorphisms in the promoter of the INS (insulin) gene, which modulate intrathymic insulin expression and can impair the elimination of insulin-responsive T cells during central tolerance

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However, mathematical modeling suggests that MCT inhibition alone may not significantly decrease lactate production due to autoregulatory feedback on flux control [213]

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Wang Y, Ni J, Gao T, Gao C, Guo L, Yin X