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The compound's therapeutic potential stems from its ability to modulate multiple cellular pathways, including extracellular matrix synthesis, metalloproteinase regulation, and inflammatory mediator control

However, inhibition of PGE 2 -EP2 only reduces demyelination when started at the same time as cuprizone treatment, not when started during peak demyelination suggesting a role for PG during the initiation of demyelination (Fig

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Filipello F, Morini R, Corradini I, Zerbi V, Canzi A, Michalski B, et al

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