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The released free fatty acids bind to UCP1 triggering an uncoupling of the proton gradient and the release of the energy of the gradient as heat

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Over 24 weeks, 266 (67%) of 395 patients in the cladribine 3.5 mg/kg group and 283 (70%) of 406 in the cladribine 5.25 mg/kg group were free from disease activity versus 145 (39%) of 373 in the placebo group

doi: 10.1371/journal.pone.0205984 169 ShioiAIkariY

Results vary depending on the individual and the treatment plan
