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The GCK (HK4) gene is located on chromosome 7p13 and is composed of 15 exons

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The aforementioned activation may consequently result in the release of substance P, neurokinin A, or calcitonin gene-related peptide (CGRP) [16]

This selective release mechanism enhances the therapeutic efficacy of ADCs while minimizing off-target effects and systemic toxicity

doi: 10.1021/acs.jmedchem.3c00136 254 WangYShiZJiangYDaiX

Science 339 , 13281331 (2013)
