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To further examine the possibility that MK-801 could convey protraction, we synthesized a series of conjugates comprising MK-801 in combination with other peptide analogues, peptide YY (PYY), glucose insulinotropic peptide (GIP) as well as a GIP/GLP-1 co-agonist, for which half-life extension has been shown to enhance weight loss efficacy 23,24,25,26

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J Clin Endocrinol Metab 89(10):50765080 Varewijck AJ, Boelen A, Lamberts SWJ et al (2013) Circulating IgGs may modulate IGF-I receptor stimulating activity in a subset of patients with Graves ophthalmopathy

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