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7.2 Relaxin-3 and the behavioral dimension of metabolic disease Relaxin-3, a member of the relaxin peptide family predominantly expressed in the nucleus incertus, signals through the RXFP3 receptor and exerts pronounced effects on feeding behavior, arousal, stress responsiveness, and cognitive processing in animal models ( At first glance, this profile appears incompatible with obesity therapy

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34 Equally, the GLP-1 mimetics exenatide, dulaglutide, liraglutide, albiglutide, and semaglutide helped preserve bone density and reduce fracture risk in older adults with T2D

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GLP-1 medications reduce appetite and increase feelings of fullness by slowing stomach emptying and acting on appetite-regulating centers in the brain, Zimmermann says

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Similarly, cystine depletion using cyst(e)inase reproduced significant tumor suppression in the KPC model (138)

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