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Finally, we compared our peptides with FOXO4-DRI peptide and found that, while FOXO4-DRI has minimal lytic activity in dividing cells, our peptides had 3-7 times higher senolytic activity (Figure 4f)

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In particular, compound with 3,4-dihydroxy substituents 23e was identified as a best inhibitor with an IC 50 value of 1.52 M