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According to one large study in 9,075 people, having higher blood levels of vitamin B12 was associated with a lower risk of obesity ( Similarly, another study in 976 people showed that having low levels of vitamin B12 was linked to a higher risk of overweight or obesity ( Whats more, a study in 256 children showed that children with lower levels of vitamin B12 tended to have a higher body mass index (BMI), which is a measure of body size determined by height and weight ( However, keep in mind that while these studies show an association between vitamin B12 status and body weight, they dont take other potentially contributing factors into account

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2021 Aug 10;97(6):e643-e646

The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes

Very high doses of oral vitamin B12 have been shown to be effective