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It leads to nutrient malabsorption, inflammation, and harmful substances entering the blood
Slowed gastric emptying means slowed intestinal motility overall
Additionally, the concentration of AOD9604 in the synovial fluid after injection was estimated to be about 0.19 mg/mL, similar to concentrations used in previous GH injection studies in animal models
These mechanisms are interesting on paper, but they come almost entirely from animals and cells
To gain further insight, a non-compartmental PK analysis was performed using gPKPDSim 74 , which revealed a 3.8-fold slower clearance rate (CL) and a 2.4-fold longer mean residence time (MRT) of QMP compared with WT albumin (Supplementary Table 4)
it fundamentally changes the peptide's behavior and, consequently, your research design
